Publications

Below is a selection of publications produced by the Hieter Laboratory, each is linked to the full abstract at PUBMED.COM.
You may also perform a search for all Hieter Labs Publications at PubMed Search.

References

  • Xu H1, Di Antonio M2,3, McKinney S1, Mathew V4, Ho B5, O’Neil NJ6, Santos ND7, Silvester J8, Wei V1, Garcia J1, Kabeer F1, Lai D1, Soriano P1, Banáth J9, Chiu DS1, Yap D1, Le DD2, Ye FB6, Zhang A4, Thu K8, Soong J10, Lin SC10, Tsai AH1, Osako T1, Algara T1, Saunders DN1, Wong J1, Xian J11, Bally MB7, Brenton JD11, Brown GW5, Shah SP1, Cescon D8,12, Mak TW8, Caldas C11, Stirling PC4, Hieter P6, Balasubramanian S2,3, Aparicio S1. CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours. Nat Commun. 2017 Feb 17;8:14432. PMID: 28211448.

  • Ang JS1, Duffy S1, Segovia R2, Stirling PC2, Hieter P3. Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase. Genetics. 2016 Nov;204(3):975-986. PMID: 27585847.

  • Duffy S1, Fam HK2, Wang YK3, Styles EB4, Kim JH5, Ang JS1, Singh T1, Larionov V5, Shah SP3, Andrews B4, Boerkoel CF2, Hieter P6. Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9967-76. PMID: 27551064.

  • Stirling PC1, Hieter P2. Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability. J Mol Biol. 2016 Jul 22. PMID: 27452366.

  • Hamza A1, Tammpere E1, Kofoed M1, Keong C1, Chiang J2, Giaever G2, Nislow C2, Hieter P3. Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants. Genetics. 2015 Nov;201(3):1263-74. PMID: 26354769.

  • Bailey ML1, Singh T1, Mero P2, Moffat J2, Hieter P3. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. Genetics. 2015 Nov;201(3):885-95. PMID: 26354767.

  • Kofoed M1, Milbury KL2, Chiang JH3, Sinha S3, Ben-Aroya S4, Giaever G3, Nislow C3, Hieter P5, Stirling PC6. An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes. G3 (Bethesda). 2015 Jul 14;5(9):1879-87. PMID: 26175450.

  • Hieter P1, Boycott KM2. Understanding rare disease pathogenesis: a grand challenge for model organisms. Genetics. 2014 Oct;198(2):443-5. PMID: 25316782.

  • Chan YA1, Hieter P2, Stirling PC3. Mechanisms of genome instability induced by RNA-processing defects. Trends Genet. 2014 Jun;30(6):245-53. PMID: 24794811.

  • Chan YA1, Aristizabal MJ2, Lu PY2, Luo Z3, Hamza A1, Kobor MS4, Stirling PC5, Hieter P6. Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip. PLoS Genet. 2014 Apr 17;10(4):e1004288. PMID: 24743342.

  • Li X1, O’Neil NJ1, Moshgabadi N1, Hieter P2. Synthetic cytotoxicity: digenic interactions with TEL1/ATM mutations reveal sensitivity to low doses of camptothecin. Genetics. 2014 Jun;197(2):611-23. PMID: 24653001.

  • Huang Y1, Minaker S, Roth C, Huang S, Hieter P, Lipka V, Wiermer M, Li X. An E4 ligase facilitates polyubiquitination of plant immune receptor resistance proteins in Arabidopsis. Plant Cell. 2014 Jan;26(1):485-96. PMID: 24449689.

  • Bailey ML1, O’Neil NJ, van Pel DM, Solomon DA, Waldman T, Hieter P. Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition. Mol Cancer Ther. 2014 Mar;13(3):724-32. PMID: 24356817.

  • Stirling PC1, Shen Y, Corbett R, Jones SJ, Hieter P. Genome destabilizing mutator alleles drive specific mutational trajectories in Saccharomyces cerevisiae. Genetics. 2014 Feb;196(2):403-12. PMID: 24336748.

  • Sajesh BV1, Bailey M, Lichtensztejn Z, Hieter P, McManus KJ. Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells. Genetics. 2013 Nov;195(3):757-67. PMID: 24002644.

  • Bhavsar AP1, Brown NF, Stoepel J, Wiermer M, Martin DD, Hsu KJ, Imami K, Ross CJ, Hayden MR, Foster LJ, Li X, Hieter P, Finlay BB. The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity. PLoS Pathog. 2013;9(7):e1003518. PMID: 23935490.

  • Braberg H1, Jin H, Moehle EA, Chan YA, Wang S, Shales M, Benschop JJ, Morris JH, Qiu C, Hu F, Tang LK, Fraser JS, Holstege FC, Hieter P, Guthrie C, Kaplan CD, Krogan NJ. From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II. Cell. 2013 Aug 15;154(4):775-88. PMID: 23932120.

  • Price JC1, Pollock LM, Rudd ML, Fogoros SK, Mohamed H, Hanigan CL, Le Gallo M; NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Zhang S, Cruz P, Cherukuri PF, Hansen NF, McManus KJ, Godwin AK, Sgroi DC, Mullikin JC, Merino MJ, Hieter P, Bell DW. Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A. PLoS One. 2013 Jun 3;8(6):e63313. PMID: 23755103.

  • van Pel DM1, Stirling PC, Minaker SW, Sipahimalani P, Hieter P. Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. G3 (Bethesda). 2013 Feb;3(2):273-82. PMID: 23390603.

  • van Pel DM1, Barrett IJ, Shimizu Y, Sajesh BV, Guppy BJ, Pfeifer T, McManus KJ, Hieter P. An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development. PLoS Genet. 2013;9(1):e1003254. PMID: 23382697.

  • O’Neil NJ1, van Pel DM, Hieter P. Synthetic lethality and cancer: cohesin and PARP at the replication fork. Trends Genet. 2013 May;29(5):290-7. PMID: 23333522.

  • Minaker SW1, Filiatrault MC, Ben-Aroya S, Hieter P, Stirling PC. Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae. Genetics. 2013 Mar;193(3):853-64. PMID: 23267056.

  • Le Gallo M1, O’Hara AJ, Rudd ML, Urick ME, Hansen NF, O’Neil NJ, Price JC, Zhang S, England BM, Godwin AK, Sgroi DC; NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Hieter P, Mullikin JC, Merino MJ, Bell DW. Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes. Nat Genet. 2012 Dec;44(12):1310-5. PMID: 23104009.

  • McLellan JL1, O’Neil NJ, Barrett I, Ferree E, van Pel DM, Ushey K, Sipahimalani P, Bryan J, Rose AM, Hieter P. Synthetic lethality of cohesins with PARPs and replication fork mediators. PLoS Genet. 2012;8(3):e1002574. PMID: 22412391.

  • Stirling PC1, Chan YA, Minaker SW, Aristizabal MJ, Barrett I, Sipahimalani P, Kobor MS, Hieter P. R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants. Genes Dev. 2012 Jan 15;26(2):163-75. PMID: 22279048.

  • Stirling PC1, Crisp MJ, Basrai MA, Tucker CM, Dunham MJ, Spencer FA, Hieter P. Mutability and mutational spectrum of chromosome transmission fidelity genes. Chromosoma. 2012 Jun;121(3):263-75. PMID: 22198145.

  • Bell DW1, Sikdar N, Lee KY, Price JC, Chatterjee R, Park HD, Fox J, Ishiai M, Rudd ML, Pollock LM, Fogoros SK, Mohamed H, Hanigan CL; NISC Comparative Sequencing Program, Zhang S, Cruz P, Renaud G, Hansen NF, Cherukuri PF, Borate B, McManus KJ, Stoepel J, Sipahimalani P, Godwin AK, Sgroi DC, Merino MJ, Elliot G, Elkahloun A, Vinson C, Takata M, Mullikin JC, Wolfsberg TG, Hieter P, Lim DS, Myung K. Predisposition to cancer caused by genetic and functional defects of mammalian Atad5. PLoS Genet. 2011 Aug;7(8):e1002245. PMID: 21901109.

  • Stirling PC1, Bloom MS, Solanki-Patil T, Smith S, Sipahimalani P, Li Z, Kofoed M, Ben-Aroya S, Myung K, Hieter P. The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genet. 2011 Apr;7(4):e1002057. PMID: 21552543.

  • Davies AH1, Barrett I, Pambid MR, Hu K, Stratford AL, Freeman S, Berquin IM, Pelech S, Hieter P, Maxwell C, Dunn SE. YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification. Oncogene. 2011 Aug 25;30(34):3649-60. PMID: 21423216.

  • Fridman Y1, Palgi N, Dovrat D, Ben-Aroya S, Hieter P, Aharoni A. Subtle alterations in PCNA-partner interactions severely impair DNA replication and repair. PLoS Biol. 2010 Oct 12;8(10):e1000507. PMID: 20967232.

  • Ben-Aroya S1, Pan X, Boeke JD, Hieter P. Making temperature-sensitive mutants. Methods Enzymol. 2010;470:181-204. PMID: 20946811.

  • Ben-Aroya S1, Agmon N, Yuen K, Kwok T, McManus K, Kupiec M, Hieter P. Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair. PLoS Genet. 2010 Feb 19;6(2):e1000852. PMID: 20174551.

  • McLellan J1, O’Neil N, Tarailo S, Stoepel J, Bryan J, Rose A, Hieter P. Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target. Mol Biol Cell. 2009 Dec;20(24):5306-13. PMID: 19846659.

  • McManus KJ1, Barrett IJ, Nouhi Y, Hieter P. Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3276-81. PMID: 19218431.

  • Rogic S1, Montpetit B, Hoos HH, Mackworth AK, Ouellette BF, Hieter P. Correlation between the secondary structure of pre-mRNA introns and the efficiency of splicing in Saccharomyces cerevisiae. BMC Genomics. 2008 Jul 29;9:355. PMID: 18664289.

  • Ben-Aroya S1, Coombes C, Kwok T, O’Donnell KA, Boeke JD, Hieter P. Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell. 2008 Apr 25;30(2):248-58. PMID: 18439903.

  • Barber TD1, McManus K, Yuen KW, Reis M, Parmigiani G, Shen D, Barrett I, Nouhi Y, Spencer F, Markowitz S, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C, Hieter P. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3443-8. PMID: 18299561.

  • Yuen KW1, Warren CD, Chen O, Kwok T, Hieter P, Spencer FA. Systematic genome instability screens in yeast and their potential relevance to cancer. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3925-30. PMID: 17360454.

  • Collins SR1, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature. 2007 Apr 12;446(7137):806-10. PMID: 17314980.

  • Martin DG1, Baetz K, Shi X, Walter KL, MacDonald VE, Wlodarski MJ, Gozani O, Hieter P, Howe L. The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3. Mol Cell Biol. 2006 Nov;26(21):7871-9. PMID: 16923967.

  • Spradling A1, Ganetsky B, Hieter P, Johnston M, Olson M, Orr-Weaver T, Rossant J, Sanchez A, Waterston R. New roles for model genetic organisms in understanding and treating human disease: report from the 2006 Genetics Society of America meeting. Genetics. 2006 Apr;172(4):2025-32. PMID: 16636111.

  • Montpetit B1, Hazbun TR, Fields S, Hieter P. Sumoylation of the budding yeast kinetochore protein Ndc10 is required for Ndc10 spindle localization and regulation of anaphase spindle elongation. J Cell Biol. 2006 Aug 28;174(5):653-63. PMID: 16923829.

  • Yuen KW1, Montpetit B, Hieter P. The kinetochore and cancer: what’s the connection? Curr Opin Cell Biol. 2005 Dec;17(6):576-82. PMID: 16233975.

  • Page AM1, Hieter P. The anaphase-promoting complex: new subunits and regulators. Annu Rev Biochem. 1999;68:583-609. PMID: 10872461.

  • Kitagawa K1, Skowyra D, Elledge SJ, Harper JW, Hieter P. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol Cell. 1999 Jul;4(1):21-33. PMID: 10445024.

  • Hyland KM1, Kingsbury J, Koshland D, Hieter P. Ctf19p: A novel kinetochore protein in Saccharomyces cerevisiae and a potential link between the kinetochore and mitotic spindle. J Cell Biol. 1999 Apr 5;145(1):15-28. PMID: 10189365.

  • Skibbens RV1, Corson LB, Koshland D, Hieter P. Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev. 1999 Feb 1;13(3):307-19. PMID: 9990855.

  • Skibbens RV1, Hieter P. Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery. Annu Rev Genet. 1998;32:307-37. PMID: 9928483.

  • Page AM1, Hieter P. The anaphase promoting complex. Cancer Surv. 1997;29:133-50. PMID: 9338100.

  • Rogic S1, Montpetit B, Hoos HH, Mackworth AK, Ouellette BF, Hieter P. Correlation between the secondary structure of pre-mRNA introns and the efficiency of splicing in Saccharomyces cerevisiae. BMC Genomics. 2008 Jul 29;9:355. PMID: 18664289.

  • McManus KJ1, Barrett IJ, Nouhi Y, Hieter P. Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3276-81. PMID: 19218431.